Current treatment options for ITP, while [there] are many, can be associated with comorbidities, unsatisfactory efficacy and duration of effect, said Catherine Broome, a study author and associate professor of medicine at the Georgetown Lombardi Cancer Center in Washington, D.C., at an ASH press conference. painful or difficult urination. Other clinical pearls, according to Aronson, include certain dietary modifications and early treatment of oral candida. Researchers said 5% to 6% of patients stopped talquetamab treatment early due to side effects. 2022 Dec 15;387(24):2287-2290. doi: 10.1056/NEJMe2208708. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody that targets GPRC5D. Talquetamab side effects. GPRC5D has limited expression on healthy human tissue but is highly expressed on malignant myeloma cells. sharing sensitive information, make sure youre on a federal These cells, made in the bone marrow, are a vital part of . We need these off-the-shelf products because not everybody is going to go to large academic centre and go through the whole CAR-T and theres great future for this. Posted: 12/11/2022 10:00:00 AM Talquetamab induced a substantial response among patients with heavily pretreated relapsed or refractory multiple myeloma. One of the things that I think is very telling with efgartigimod is, no matter what subgroup we looked at, it showed a benefit over placebo, said Broome. Lindsay Diamond, MSN, AGNP-C, AOCNP, discusses findings from CheckMate 274 and other data presented during the 2023 ASCO Genitourinary Cancers Symposium. Side effects were relatively frequent, but typically mild. The most surprising and disappointing problem I've encountered is the loss of my sense of taste. Tecvayli appeared well tolerated. Heres the joy part. A total of 5 patients experienced dose interruptions because of a TEAE. "With a median follow-up of 14.9 months (range 0.5+ to 29.0), 74.1 percent of patients treated at the SC [subcutaneous] 0.4 mg/kg dose administered weekly achieved a response, 59.4 percent achieved a very good partial response or better, 33.6 percent achieved a complete response or better and 23.8 percent achieved a stringent complete response," reported pharmaceutical company Johnson & Johnson in a press release. I just get excited when I attend ASH and I see so many stellar people doing what seem to be super-human things by coming up with these life-lengthening miracles that just might possibly keep me alive until theres a cure. experts. This means slippery stuff [that] goes down, she explained. a condition causing fever, vomiting, shortness of breath, headache and low blood . 2023 Mar 18;15(6):1839. doi: 10.3390/cancers15061839. This means that three-quarters of these patients are looking at a new lease on life, said Dr. Chari, of the Tisch Cancer Institute at Mount Sinai in New York. Known as a bispecific T-cell engager antibody, this treatment is a relatively new kind of immunotherapy approach. Cure Hub Side Effect Solutions My Journal University Coach Connect . The primary end points - the frequency and type of dose-limiting toxic effects (study part 1 only), adverse events, and laboratory abnormalities - were assessed in order to select the recommended doses for a phase 2 study. The median time to onset was 26.5, 6.7, and 41.5 days, respectively. scaling of the skin. Talquetamab for relapsed/refractory multiple myeloma: Results from a Janssen is responsible for the development and commercialization of talquetamab. 1. doi: 10.1016/j.bulcan.2021.10.003. Presented at: European Hematology Association Congress 2022; June 9-12, 2022; Vienna, Austria. A Promising New Treatment Emerges For Multiple Myeloma Between the Lines Podcast: Updates in Use of Proteasome Inhibitors for Relapsed/Refractory Multiple Myeloma. Injection-site reactions were observed in 7.9% of patients. There's been amazing progress in the area of immunotherapy. SOHO State-of-the-Art Updates and Next Questions | BCMA-Directed CAR T-Cells: Early Results and Future Directions. Janssen Presents Updated Results Evaluating First-in-Class Talquetamab This one, talquetamab, came up with some different side effects. Known in full as G protein-coupled receptor, family C, group 5, member D, the protein found on cancerous plasma cells drew attention over the weekend as Johnson & Johnson unveiled new data for an experimental multiple myeloma treatment. In total 70% of patients experienced Cytokine Release Syndrome (CRS) but all events were minor. Many of those with a very good partial response had a 90% improvement., He told MNT that phase 3 trials are now underway using a the 2-weekly dosing pattern. (2016). We have lot of patients start a nail hardener at the onset of therapy.. Like BCMA, Talquetamabs target, GPRC5D, is found on most myeloma cells. Taltz | European Medicines Agency Reducing Medical and Other Debt Through Negotiation, Getting Fit and Keeping Bones Safe (Live Exercise Demo), SouthEast Myeloma Community- Understanding Immunotherapy. . Track your myeloma and find treatment options, Journal your myeloma story in video, audio and writing, Learn from 150+ myeloma experts in video lessons, Find a free personal coach to help navigate your myeloma, Join our new social media app for myeloma patients, Tackle challenges and crush your fitness goals together, Stay up-to-date with thousands of myeloma news articles, Listen to one-on-one interviews with experts on clinical trials, Attend in-person meetings with myeloma experts, Join community groups with other patients and caregivers, Answer survey questions to advance myeloma research, Find answers to commonly asked questions when navigating HealthTree services. June 29, 2022. (December 10, 2021) Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma. It also featured important updates on Bluebird bios gene therapy for beta thalassemia and sickle cell disease, data for which have been a conference mainstay for nearly a decade. Scientists use genetic rewiring to increase lifespan of cells. Recent updates on bispecific T-cell engager (BiTE) antibodies in The most common side effects reported in the clinical trial for Tecvayli were hypogammaglobulinaemia (a condition in which the level of immunoglobulins (antibodies) in the blood is low and the risk of infection is high), cytokine release syndrome (CRS) (i.e. The CRS was low-grade without associated mortality. But a new kind of therapy, a bispecific antibody called Talquetamab, has been showing pro . Talquetamab appears to have a have favorable risk/benefit profile in RRMM with durable responses and manageable toxicities. Multiple myeloma is a cancer of plasma cells. In patients with multiple myeloma, GPRC5D is overexpressed and . Talquetamab is under investigation in clinical trial NCT04634552 (A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma).
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