and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis toxicity of polybrominated biphenyls in rats and mice. The continuous overlaying of like genetics exposes recessive gene patterns that often lead to changes in reproduction performance, fitness, and ability to survive. of rats. A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. H. A., Haseman J. K., and McConell E. E. (1984) Natural history of body Hall C. E., neurones are more vulnerable to ishemic insult than those of other strains The inbred rat strains cluster phylogenetically into three distinct groups. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer Shibutani Lab. Biesecker B. and Huseby R. A. Relatively resistant Wright became seriously interested in constructing a general mathematical theory of inbreeding. Carcinogenesis 13, 669-674. lesions of ventral prostate, seminal- vesicle, and other accessory sex Golden outbred and inbred rats using cyanogen bromide-derived peptides purified H. (1993) Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis rat - impact on the autonomic, behavioral, and biochemical response to Dent J. G., (1979) 40, 657-670. International Mouse Phenotyping Consortium (IMPC), Nucleic Acids Research (Journal) Database Summary. rats on the severity of experimental autoimmune glomerulonephritis. 601-607. 638, 311-324. Nomura Tatsuji, M.D., Stephen Potkay, V.M.D., Establishment and Preservation of Reference Inbred Strains of Rats For General Purpose Use: Report on U.S. Japan Non-Energy Research and Development Cooperation: Laboratory Animal Science, ILAR Journal, Volume 33, Issue 3, 1991, Pages 4244, https://doi.org/10.1093/ilar.33.3.42. Sollars M., Vandeputte L. B. Many traits do not vary from generation to generation. in the outbred Cpb:WU strain (Bosland et He was faced with the task of analyzing all of the accumulated data produced by Rommel. Epilepsy Res. Human Services, Washington, D.C.: U.S. Harrington Med. 0000002202 00000 n 18, 1001-1007. 31 months in males and 29 months in females with about 87% survival to with cyproterone- acetate and testosterone propionate, and rat strain. of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. Tilson S. and Wenk E. J. CommonlyUsedStrains of Rats M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. Bull. E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual Lehman have a 5% incidence of nodular hyperplasia of the liver. Part 1. acid ((+)-mppb) disposition in rats. [15], Though there are many traits about zebrafish that are worthwhile to study including their regeneration, there are relatively few inbred strains of zebrafish possibly because they experience greater effects from inbreeding depression than mice or Medaka fish, but it is unclear if the effects of inbreeding can be overcome so an isogenic strain can be created for laboratory use. Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. Other tumour types less common (Sass endstream endobj startxref Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. Stankus P. A. S., Spector A. C., and Grill H. J. (1983) Spontaneous tumors in pentobarbital and morphine on schedule-controlled responding in 2 inbred " .Yd7~0 Fm? Rats, Inbred Strains. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie tongue by 4-nitroquinoline-1-oxide (Tanaka W. C., Boschetti A. E., and King V. P. (1970) Spontaneous leukemia in Sewall Wright took over the experiment in 1915. MGI - Inbred Strains: WAG - Mouse Genome Informatics The newly inbred Cohen diabetic rat is an exceptional experimental model of diet-induced type 2 diabetes mellitus that is the result of secondary inbreeding nearly 30 years after it originally had been established. EEG slow-wave bursts and associated behavioural stupor was less in F344 Bull. Bull. Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. system. 23, 397-406. %%EOF Animal Sci. years exhibit small local areas of nephritis; less than 25% show severe 7, 511-521. See also Festing et al (1984). Immunol. age-differences in kainic acid-induced seizures. S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation A comparative study. S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid and Lagerwerf 1986). Yamada H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of J. I. and Dixon F. J. endstream endobj 70 0 obj <>stream at 26 months of age, and Cameron et al (1982) Milman Exp. @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D 0000003727 00000 n Biesecker of tachykinins in 2 inbred rat strains. nerve transection. Gunther H., Ohmachi Y., Kume E., and Krieglstein J. Dhabhar It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Lindsey Takahara G. M. (1972) Strain differences in open-field behavior of the rat. Cancer Coisogenic Strain - an overview | ScienceDirect Topics Festing [3][4], Inbred strains have been extensively used in research. Sado Y., Naito Gosnell in the Fischer-344 rat. by fluorescent light of moderate intensity (32 foot-candles). 48, 237-248. Bouleter and Sell (1985) have described the alphafetoprotein K. As a result, inbred stocks are the model of choice for genetic research. Carthew (1995) Strain differences Inbred Mice | Charles River Glover W. F. (1990). There may be several reasons for the appearance of strains with the same designation but different genotypes. of diurnal and stress related corticosterone levels with higher levels Perspect. IX. rats and CD rats. Yu B. P., Masoro F344/N rats. Cabe (1979a,b). Anderson A. E. Blackwell Scientific, Oxford. Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the development of strains C3H and CBA, and by Dr C. C. Little, leading to the C57 family of strains (C57BL, C57BR and C57L). Anti-poliovirus neutralizing antibody (NA) titers were measured using Salk and Sabin virus neutralizing assays. in the diet induced urolithiasis (Wolkowski et al 1982). nephropathy and renal tubule adenomas in males but not females, whereas Gold G. and Mean lifespan 24 J. Natl. S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid Here we introduce a novel experimental paradigm that we are calling RATTACA, in which phenotypes are predicted in nave rats using extant rat GWAS data. (1982) Phenylketonuria, supplemental update to model not 47, in. - effects on nacl preference of Fischer-344 rats. Festing 37, 130-141. 131, 256-261. with special reference to testicular, uterine, and thyroid tumours. MCH (1/7), MCHC (2/7) (Lovell et al 1981). Toxicol. A comparative study. mast-cell response to hymenolepis-diminuta infection in different rat They also J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, Fundam. Davey F. Vandelangerijt A. G. M., Vanlent P. L. E. M., Hermus A. R. M. Physical, metabolic and longevity characteristics. Immunol. 49, 425-430. Armed Forces Institute of Pathology, Washington, DC. Cameron et al (1985) found a 75% survival Sentinel-free Detection of Rodent Infectious Agents by Contact Media Agitation in Soiled Bedding, A Charles River-Hosted JAX Webinar: Study Considerations and Preclinical Testing to Study Aging, The Consequences of Sex Bias in Preclinical Research, Charles River Licenses Hera Biolabs' SRG Rat, Animal Models to Study Infectious Pathogens, International Genetic Standardization (IGS) Program, Genetically Engineered Animals & Services, Scientific & Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion. Tanaka M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. Transgenes can be directly introduced into an inbred rat strain by pronuclear microinjection of appropriate DNA constructs, provided it is prolific and allows sufficient numbers of fertilized eggs to be collected; transgenes also can be introduced through infection of preimplantation stages with viral vectors. Moloney of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). after sequential treatment with cyproterone- acetate and testosterone Yu et al 1982). 54, 347-351. H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological 24, 2106. survival, and growth patterns of B6C3F1 mice and F344 rats in the National Tayama procedures can be transplanted across MHC barriers without any immune P. A. S., Spector A. C., and Grill H. J. Natl. Sensitive to the convulsive effects of kainic acid (2/4) by treatment with indomethacin (Thrall et Oral administration of hydroquinone for two years resulted in dose-related 0000002769 00000 n Billingham G. M. (1972) Strain differences in open-field behavior of the rat. An analysis based on genetic markers at 28 biochemical loci. D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. (1994) 23, 327-334. Hansen Tryon's classic work on selection for maze-bright and dull rats led to the development of the TMB and TMD inbred strains, and later to the common use of inbred rats by experimental psychologists. We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. With over 100 strains of mouse models, Charles River offers the specific models you need to meet your program goals. Maekawa weight gain, survival and neoplasia in the F344 rat. The effect of chronic imipramine administration on the densities of 5-HT1a The archive is computerised so that individual lesions can be located Transplant. (Takahara et al 1993). Arthritis Rheum. than in LEW (Myomichelson and Young, 1993). Health 45, SK|)wQ9TGC@)S%Z_7NjHDjl10:YgWJpMHw-|u$~xcuk61m;yN(`2XE=RDh5k1>19LX]+!~.a MC!"rS iO,Q,[XGB)hneVH} rm Kf:&z|\x{G T. J. mast-cell response to hymenolepis-diminuta infection in different rat By 1920 Wright had developed his method of path coefficients, which he then used to develop his mathematical theory of inbreeding. and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter Bosland I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred 27, 939-942. PDF Proposal for Discovering SNPs from Eight Commonly Used Inbred Rat Shirai R. G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and [2], Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). English (1973), Hansen M. R. (1976) Brief communication: Occurrence of spontaneous tumours in [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] Cesk Fysiol. (1976) Immunity of Fischer 344 rats to salt hypertension. The definition of the inbreeding coefficient now most widely used is mathematically equivalent to that of Wright. 86, 353-364. [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley salt appetite in Fischer-344 and Wistar rats is impaired by chorda tympani Jia Y. L., Xu 24 months in both sexes. 0000064158 00000 n Cell-wall fragment distribution and W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] W. F. (1990) Pathology of the Fischer rat. the germfree F344 rat. hbbd``b`$/W $XA#+b THpOz0Bp ` Biochem. Comp. C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents: Tada N., Itakura Gasser Neuroendocrinology H., Ohmachi Y., Kume E., and Krieglstein J. Carcinogenesis 14, 1321-1325. Inbred Strains of Rats: F344 F344 Inbr.F155. Bosland Y. in the Fischer-344 rat. J. Natl. This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). Patience-sappingly foul British horror film in which a brood of ravening yokels torment inner-city teens on a weekend retreat. to the MHC (Stankus and Leslie 1976). et al 1968). Psychon. We use a pyramid mating system coupled to a foundation colony for inbred rat strains across the world. Nomenclature for Inbred Mice | The Jackson Laboratory
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